Fig 1: Paeoniflorin modulated circ-PREX1/miR-140-3p/WNT5B axis in IL-1β-induced human chondrocytes in vitro. A Western blotting examined WNT5B protein level in IL-1β-induced C28/I2 cells pre-transfected with si-NC, si-circ-PREX1, si-circ-PREX1 and anti-miR-NC, or si-circ-PREX1 and anti-miR-140-3p. B, C Western blotting examined WNT5B protein level in IL-1β-induced C28/I2 cells pre-transfected with circ-PREX1, pcDNA, anti-miR-140-3p, or anti-miR-NC, and then treated with paeoniflorin (50 μM) for 4 h. *P < 0.05